Acute angioedema in Cape Town emergency centres and a suggested algorithm to simplify and improve management.

BACKGROUND: Angioedema is the most common acute allergic presentation to emergency centres (EC), with hospitalisation rates increasing in high-income countries. Angioedema can complicate with life-threatening laryngeal obstruction. There are no local data; therefore, we aimed to characterise acute angioedema cases presenting to ECs and develop a simple management algorithm. OBJECTIVE: To characterise the clinical presentation, management and outcomes of acute angioedema cases presenting to ECs. Based on these findings, we developed a management algorithm for acute angioedema to improve the care of acute angioedema in South Africa (SA). METHODS: We conducted a retrospective folder review of all patients admitted to Groote Schuur Hospital (tertiary) and Mitchells Plain District Hospital (secondary) ECs from 1  June 2018 to 31  June 2020. Using ICD-10 coding, folders of adults ≥18 years with possible angioedema presenting to the ECs were screened. An allergist extracted demographics, medical history, management and outcome data for each angioedema event. RESULTS: A total of 142 acute angioedema episodes were included, with a median (interquartile range) age of 42 (28 - 58) years, and 62% of patients were female. The majority (124/142, 87%) of acute angioedema EC presentations involved swelling above the shoulders, with airway involvement in 20 (14%) patients, with two patients requiring intubation. Nineteen (13%) patients required admission, with five (26%) admitted to high care/intensive care. Drug-induced angioedema was the most common cause, with 64/142 (45%) linked to a known offending drug, 42/64 (65.6%) being angiotensin-converting enzyme inhibitor (ACE-I). Critical information to guide angioedema management, including past personal/family allergy history, and duration of angioedema prior to EC visit, was not recorded in 64.7% and 37.8% of EC records, respectively. Unnecessary treatment with corticosteroids or antihistamines occurred in 19/53 (36%) and 16/53 (30%) cases with bradykinin-mediated angioedema ACE-I angioedema and hereditary angioedema). Overall, only 36/142 (25%) of angioedema patients were connected to allergy care. CONCLUSION: Angioedema is the most common allergy presentation to two ECs in Cape Town, SA. Bradykinin-mediated angioedema secondary to ACE-I therapy is the single most common offender, and was not appropriately managed in more than a third of cases. Based on these findings, we have developed a management algorithm that easily stratifies patients into bradykinin or mast cell-mediated angioedema with a step-by-step management approach that is applicable to the SA context. Ongoing awareness and education on allergy emergencies are required to ensure accurate diagnosis of less common causes of angioedema (particularly bradykinin-mediated angioedema) and linkage to allergy specialist care.

The use of emergency medical services for palliative situations in Western Cape Province, South Africa: A retrospective, descriptive analysis of patient records.

BACKGROUND: An estimated 56.8 million people require palliative care annually, while only 14% receive such care. This imbalance is particularly acute in low-to middle-income countries (LMICs), where up to 80% of patients requiring palliative care reside. To correct this imbalance, integration between palliative services and other disciplines has been recommended. While improved palliative care integration is a priority in the South African (SA) LMIC context, emergency medical services (EMS) and palliative care remain non-integrated. This has resulted in poor palliative situation management by EMS and a lack of research concerning their intersection. OBJECTIVE: To examine EMS use for palliative situations in the Western Cape (WC) Province of SA by describing frequency of intersection, patient characteristics and outcomes. METHODS: An observational, descriptive, retrospective patient record review was employed at two hospitals with palliative care services in the WC. All patient records of those who arrived at the hospitals between 1 January 2020 and 31 December 2020 via EMS conveyance leading to palliative care provision were included in the study. RESULTS: In total, 1 207 unique patients received palliative care services at both hospitals during the study period. Of these, 395 (33%) made use of EMS for hospital conveyance on 494 occasions. The median (range) patient age was 60 (20 - 93) years, and most transports involved male patients (54%, n=265). Family members were the primary caregivers in most instances (89%, n=440), dyspnoea was the chief complaint (36%, n=178) and cancer was the most frequent diagnosis (32%, n=159). The median length of hospital stay was 6 days, with most patients discharged home (60%, n=295). CONCLUSION: EMS in SA frequently encounter palliative situations for symptoms that may be managed within their scope of practice. Consequently, it appears that EMS have an important role to fulfil in the care of patients with palliative needs. Integrating EMS and palliative care may result in improved palliative care provision and, therefore, EMS and palliative care integration would be beneficial in SA.

Perceived stressors of oral hygiene students in the dental environment

Background. University students are exposed to a multitude of stressors that may impact on their performance. The nature of health sciences education generally involves early engagement with patients and communities; which may add to the stressors inherent to university life. There is sparse information on stressors in the oral hygiene educational environment. Objective. To determine perceived stressors and the level of burnout among oral hygiene students at the University of the Western Cape; Cape Town; South Africa. Method. A descriptive; cross-sectional study design was used. The study sample included all students in the Bachelor of Oral Health (BOH) degree during 2012 (N=89). A self-administered questionnaire was used to gather data. Three parameters were measured; i.e. (i) demographic characteristics; (ii) perceived sources of stress; using a modified Dental Environment Stress (DES) questionnaire; and (iii) burnout; using the Maslach Burnout Inventory (MBI). Results. Respondents were mostly female (74%) and primarily in the 18 - 25-year age group (92%). First- and 2nd-year students identified fear of failing and study load as major stressors. Stressors related to a lack of basic needs were identified as major stressors by 25% of 1st-year students. Third-year students identified clinical quotas; supervision and patients being late as major stressors. MBI scores indicated that students were not at risk forburnout; however; most students (66.2%) scored high on emotional exhaustion (EE). Conclusion. Oral hygiene students identified stressors in their learning environment. There was a progressive increase in EE across academic years. The results suggest that interventions should be tailored for specific academic year groups

Comparing the performance of storage phosphor plate and Insight film images for the detection of proximal caries depth.

OBJECTIVES: To compare proximal caries depth between conventional film images, unenhanced and enhanced storage phosphor plate images. METHOD: Bitewing radiographs were taken on 100 patients presenting for Conservative and Periodontal treatment. Only one bitewing was taken on a patient either the right or left hand side of the patient A DenOptics storage phosphor plate and size 3 Kodak Insight film were simultaneously placed into a Rinn bitewing holder. The Insight film was placed behind the phosphor plate. Both were simultaneously exposed to radiation. The unenhanced phosphor plate images were copied four times. Contrast and brightness were either increased or decreased on the copied images. A five point scale was chosen for proximal caries depth: 0--sound, 1--caries in enamel, 2--caries reaching dentino-enamel junction, 3--caries into dentine, 4--caries in a restored area. The bitewing images were evaluated by 4 clinicians. Images with technical errors were excluded from the study. RESULTS: Altogether 1848 tooth surfaces were evaluated of which 136 surfaces were excluded due to technical errors. The results show that for the detection of proximal caries there is no significant difference in accuracy between unenhanced storage phosphor plate and Kodak Insight film images (p > 0.001). When decreasing both contrast and brightness there was no significant difference in diagnostic accuracy (p > 0.001) between unenhanced and enhanced storage phosphor plate images. More surfaces were analyzed for caries into the dentine on the enhanced images when both contrast and brightness were increased. CONCLUSION: Although contrast-enhanced and brightness-enhanced images retween conventional film, unenhanced and enhanced images.

The use of fractal analysis to reveal remodelling in human alveolar bone following the placement of dental implants.

In order to confirm the presence of adequate bone support for implants it is necessary to examine the surrounding bone at intervals. While this may be attempted by looking for changes in serial radiographs, such comparisons are inaccurate unless standardized procedures are followed which allow subtraction of consecutive digital images. As image textures are less susceptible to magnification distortion, it was decided to examine the fractal dimensions of successive radiographs of bone after implant placement. All available panoramic radiographs for each of 18 patients who had received fixed implant-supported prostheses were digitized. A window of bone adjacent and distal to the most posterior implant was defined as the region of interest; the fractal dimension of the image was calculated. Linear regression was used to investigate whether there were any significant shifts in fractal dimension during the recall period after implantation. A significant increase in fractal dimension was found during the period up to 2 yr after implantation (p < 0.001). The most pronounced increase was in the region of bone around the neck of the implant. An increase in orientation of the image in a direction oblique to the implant was also found during the same period. These changes are consistent with models derived from finite-element analysis that predict the relation between trabecular architecture and strain. One subject's radiographs had a significant negative regression slope, which further monitoring may reveal was an early sign of implant failure. The satisfactory remodelling of bone in response to implant placement may be monitored using a texture analysis of routine orthopantomograms.